Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

Published:2021-04-06 Issue:8 Volume:64 Page:4913-4946
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rohde Jason M.¹,Karavadhi Surendra¹,Pragani Rajan¹,Liu Li¹,Fang Yuhong¹,Zhang Weihe²,McIver Andrew²,Zheng Hongchao²,Liu Qingyang²,Davis Mindy I.¹,Urban Daniel J.¹,Lee Tobie D.¹,Cheff Dorian M.¹,Hollingshead Melinda³,Henderson Mark J.¹^ORCID,Martinez Natalia J.¹,Brimacombe Kyle R.¹,Yasgar Adam¹^ORCID,Zhao Wei¹^ORCID,Klumpp-Thomas Carleen¹,Michael Sam¹,Covey Joseph⁴,Moore William J.⁵,Stott Gordon M.⁵,Li Zhuyin¹,Simeonov Anton¹,Jadhav Ajit¹,Frye Stephen²^ORCID,Hall Matthew D.¹^ORCID,Shen Min¹,Wang Xiaodong²^ORCID,Patnaik Samarjit¹^ORCID,Boxer Matthew B.¹

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Center for Integrative Chemical Biology and Drug Discovery, Division for Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, United States

3. Biological Testing Branch, Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland 21702, United States

4. Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland 20850, United States

5. NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00019

Reference41 articles.

1. Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities