Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode-Reference-Cited by-同舟云学术

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode

Published:2022-02-11 Issue:4 Volume:65 Page:3359-3370
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boffey Helen K.¹,Rooney Timothy P. C.¹^ORCID,Willems Henriette M. G.¹,Edwards Simon¹,Green Christopher²,Howard Tina³,Ogg Derek³,Romero Tamara¹,Scott Duncan E.¹^ORCID,Winpenny David¹,Duce James¹,Skidmore John¹^ORCID,Clarke Jonathan H.¹^ORCID,Andrews Stephen P.¹^ORCID

Affiliation:

1. The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.

2. UK Dementia Research Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.

3. Peak Proteins, Alderley Park, Macclesfield SK10 4TG, Cheshire, U.K.

Funder

Alzheimer's Research Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01819

Reference38 articles.

1. Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

2. Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease