Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations
Author:
Affiliation:
1. Athenex Inc., Conventus Building, Buffalo, New York 14203, United States
2. Institute of Molecular Biology and Biophysics, ETH Zürich, Otto-Stern-Weg 5, 8093 Zürich, Switzerland
Funder
Schweizerischer Nationalfonds zur F??rderung der Wissenschaftlichen Forschung
Athenex Inc
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01272
Reference72 articles.
1. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
2. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research
3. Co-administration of cyclosporin enables oral therapy with paclitaxel
4. Interaction of Docetaxel (“Taxotere”) with Human P-Glycoprotein
Cited by 38 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Investigating how HIV-1 antiretrovirals differentially behave as substrates and inhibitors of P-glycoprotein via molecular dynamics simulations;Computational and Structural Biotechnology Journal;2024-12
2. Mechanistic insights into P-glycoprotein ligand transport and inhibition revealed by enhanced molecular dynamics simulations;Computational and Structural Biotechnology Journal;2024-12
3. Discovery of pyridoquinoxaline-based new P-gp inhibitors as coadjutant against Multi Drug Resistance in cancer;European Journal of Medicinal Chemistry;2024-10
4. Mutational analysis reveals the importance of residues of the access tunnel inhibitor site to human P‐glycoprotein (ABCB1)‐mediated transport;Protein Science;2024-08-28
5. Encequidar Mesylate Novel Degradation Products: Isolation, Characterization, and Structural Evaluation Using Mass‐Triggered Preparative HPLC, HRMS, and NMR Techniques;SEPARATION SCIENCE PLUS;2024-08-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3