Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming-Reference-Cited by-同舟云学术

Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming

Published:2021-12-21 Issue:1 Volume:65 Page:460-484
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sheng Yuwen¹²,Chen Yuwen¹³⁴^ORCID,Zeng Zhongqiu¹²,Wu Wenbi⁴,Wang Jing¹,Ma Yuling¹,Lin Yuan¹⁵,Zhang Jichao¹,Huang Yulan⁴,Li Wenhua¹,Zhu Qiyu¹,Wei Xiao¹³,Li Suiyan³,Wisanwattana Wisanee¹²,Li Fu¹^ORCID,Liu Wanli⁶,Suksamrarn Apichart⁷,Zhang Guolin¹⁸,Jiao Wei¹,Wang Fei¹⁸^ORCID

Affiliation:

1. Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

4. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China

5. Sichuan Xincheng Biological Co., LTD, Chengdu 611731, China

6. Ministry of Education Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China

7. Department of Chemistry and Center of Excellent for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand

8. Xiongan Institute of Innovation, Chinese Academy of Sciences, Hebei 071700, China

Funder

Thailand Research Fund

National Natural Science Foundation of China

Chinese Academy of Sciences

Western Light Foundation of Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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