Design of a Potent TLX Agonist by Rational Fragment Fusion-Reference-Cited by-同舟云学术

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Design of a Potent TLX Agonist by Rational Fragment Fusion

Published:2022-01-06 Issue:3 Volume:65 Page:2288-2296
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Faudone Giuseppe¹,Zhubi Rezart¹²,Celik Fatih¹,Knapp Stefan¹²^ORCID,Chaikuad Apirat¹²^ORCID,Heering Jan³^ORCID,Merk Daniel¹⁴^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt, Germany

2. Structural Genomics Consortium, BMLS, Goethe University Frankfurt, D-60438 Frankfurt, Germany

3. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, D-60596 Frankfurt, Germany

4. Department of Pharmacy, Ludwig-Maximilians-Universität München, D-81377 Munich, Germany

Funder

Wellcome Trust

Structural Genomics Consortium

Aventis Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01757

Reference29 articles.

1. The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone

2. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

3. Transrepressive Function of TLX Requires the Histone Demethylase LSD1

4. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1

5. The Oncoprotein BCL11A Binds to Orphan Nuclear Receptor TLX and Potentiates its Transrepressive Function

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1. Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools;Journal of Medicinal Chemistry;2024-09-05

2. Lack of Nr2e1 expression in hepatocytes impaired cell survival and aggravated palmitate-induced oxidative stress;Advances in Medical Sciences;2024-09

3. Imidazole and Quinoline-Based Promising Agent for Cancer Treatment; Synthesis, Characterization, and Computational Calculations;Afyon Kocatepe University Journal of Sciences and Engineering;2024-07-23

4. Chemogenomics for NR1 nuclear hormone receptors;Nature Communications;2024-06-18

5. Defining a vitamin A5/X specific deficiency – vitamin A5/X as a critical dietary factor for mental health;International Journal for Vitamin and Nutrition Research;2024-06

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