Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models
Author:
Affiliation:
1. Merck KGaA, Global Research & Development, Frankfurter Strasse 250, 64293 Darmstadt, Germany
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00800
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1. APC, Signal transduction and genetic instability in colorectal cancer
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4. Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition
5. PARPs in genome stability and signal transduction: implications for cancer therapy
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