APC, Signal transduction and genetic instability in colorectal cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/35094067.pdf
Reference153 articles.
1. Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159–170 (1996).
2. Powell, S. M. et al. APC mutations occur early during colorectal tumorigenesis. Nature 359, 235–237 (1992).Analysis of sporadic colorectal tumours showed that APC mutations are present in the earliest tumour stages, and that the frequency of such mutations remains constant as tumours progress from benign to malignant stages.
3. Polakis, P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim. Biophys. Acta 1332, F127–F147 (1997).
4. Fodde, R. et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biol. 3, 433–438 (2001).APC -mutant embryonic stem cells have extensive chromosomal, centrosomal and spindle aberrations, providing evidence for a role of APC in CIN. APC accumulates at the kinetochore during mitosis.
5. Kaplan, K. B. et al. A role for the Adenomatous polyposis coli protein in chromosome segregation. Nature Cell Biol. 3, 429–432 (2001).Cells carrying a truncated APC gene ( ApcMin) are defective in chromosome segregation. During mitosis, APC localizes to the ends of microtubules embedded in kinetochores and forms a complex with the checkpoint proteins BUB1 and BUB3. In vitro , APC is a high-affinity substrate for BUB kinases.
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