Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate-Reference-Cited by-同舟云学术

Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate

Published:2022-01-07 Issue:3 Volume:65 Page:2262-2287
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Humphreys Philip G.¹^ORCID,Atkinson Stephen J.¹^ORCID,Bamborough Paul¹^ORCID,Bit Rino A.¹,Chung Chun-wa¹^ORCID,Craggs Peter D.¹,Cutler Leanne¹,Davis Rob¹,Ferrie Alan¹,Gong GangLi²,Gordon Laurie J.¹,Gray Matthew¹,Harrison Lee A.¹^ORCID,Hayhow Thomas G.¹,Haynes Andrea¹,Henley Nick¹,Hirst David J.¹,Holyer Ian D.¹,Lindon Matthew J.¹,Lovatt Cerys¹,Lugo David¹,McCleary Scott¹,Molnar Judit¹,Osmani Qendresa¹,Patten Chris¹,Preston Alex¹^ORCID,Rioja Inmaculada¹,Seal Jonathan T.¹^ORCID,Smithers Nicholas¹,Sun Fenglai²,Tang Dalin²,Taylor Simon¹,Theodoulou Natalie H.¹³,Thomas Clare¹,Watson Robert J.¹,Wellaway Christopher R.¹^ORCID,Zhu Linrong²,Tomkinson Nicholas C. O.³^ORCID,Prinjha Rab K.¹

Affiliation:

1. GlaxoSmithKline R&D, Stevenage, Hertfordshire SG1 2NY, United Kingdom

2. WuXi Shanghai STA Pharmaceutical R&D Co., Ltd., No. 90 Delin Road, WaiGaoQiao Free Trade Zone, Shanghai 200131, China

3. WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom

Funder

Engineering and Physical Sciences Research Council

University of Strathclyde

GlaxoSmithKline Research and development, Stevenage

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01747

Reference58 articles.

1. The Bromodomain: A New Target in Emerging Epigenetic Medicine