From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor-Reference-Cited by-同舟云学术

From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor

Published:2021-11-15 Issue:2 Volume:65 Page:1481-1504
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Turner Lewis D.¹^ORCID,Trinh Chi H.²,Hubball Ryan A.¹^ORCID,Orritt Kyle M.¹,Lin Chi-Chuan²,Burns Julie E.³,Knowles Margaret A.³,Fishwick Colin W. G.¹^ORCID

Affiliation:

1. School of Chemistry, University of Leeds, Leeds, LS2 9JT, U.K.

2. Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, U.K.

3. Leeds Institute of Medical Research at St James’s, University of Leeds, Leeds, LS9 7TF, U.K.

Funder

Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01163

Reference79 articles.

1. Cellular signaling by fibroblast growth factor receptors

2. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

3. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

4. Autophosphorylation of FGFR1 Kinase Is Mediated by a Sequential and Precisely Ordered Reaction

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