Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme-Reference-Cited by-同舟云学术

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme

Published:2021-07-22 Issue:15 Volume:64 Page:11302-11329
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hamilton Matthew M.¹^ORCID,Mseeh Faika¹,McAfoos Timothy J.¹,Leonard Paul G.¹,Reyna Naphtali J.¹,Harris Angela L.²,Xu Alan¹,Han Michelle¹,Soth Michael J.¹^ORCID,Czako Barbara¹^ORCID,Theroff Jay P.¹,Mandal Pijus K.¹,Burke Jason P.¹,Virgin-Downey Brett¹,Petrocchi Alessia¹,Pfaffinger Dana¹,Rogers Norma E.¹,Parker Connor A.¹,Yu Simon S.¹,Jiang Yongying¹,Krapp Stephan³,Lammens Alfred³,Trevitt Graham⁴,Tremblay Martin R.⁵,Mikule Keith⁵,Wilcoxen Keith⁵,Cross Jason B.¹,Jones Philip¹,Marszalek Joseph R.²,Lewis Richard T.¹

Affiliation:

1. IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States

2. TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States

3. Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Martinsried, Germany

4. XenoGesis Ltd, BioCity Nottingham, Pennyfoot Street, Nottingham, Nottinghamshire NG1 1GF, U.K.

5. Tesaro Inc., 1000 Winter Street, Waltham, Massachusetts 02451 United States

Funder

University of Texas System

Tesaro Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00679