Rational Design for Nitroreductase (NTR)-Responsive Proteolysis Targeting Chimeras (PROTACs) Selectively Targeting Tumor Tissues
Author:
Affiliation:
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
2. Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China
Funder
Graduate Research and Innovation Program in Jiangsu Province, China
College Student Innovation and Entrepreneurship Train Program
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02221
Reference43 articles.
1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
2. Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation
3. Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation
4. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders
5. Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
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