Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion-Reference-Cited by-同舟云学术

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Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion

Published:2021-02 Issue: Volume:211 Page:113091
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Qiu Xiaqiu,Li Yuanqing,Yu Bin,Ren Jie,Huang Huidan,Wang Min,Ding Hong,Li Zhiyu,Wang Jubo,Bian Jinlei

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference42 articles.

1. Cell cycle, CDKs and cancer: a changing paradigm;Malumbres;Nat. Rev. Canc.,2009

2. Activating p53 and inhibiting super enhancers to cure Leukemia;Ball;Trends Pharmacol. Sci.,2018

3. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer;Blake;Sci. Signal.,2019

4. CDK9 inhibitors reactivate p53 by downregulating iASPP;Wu;Cell. Signal.,2020

5. Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma;Narita;Blood,2017

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1. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity;European Journal of Medicinal Chemistry;2024-09

2. CDK9 targeting PROTAC L055 inhibits ERα-positive breast cancer;Biomedicine & Pharmacotherapy;2024-08

3. Exploration of Potential Cyclin-dependent Kinases and their Inhibitors to Combat Abnormal Signalling and Cancer;Current Signal Transduction Therapy;2024-07

4. Hydrophobic tagging of small molecules: an overview of the literature and future outlook;Expert Opinion on Drug Discovery;2024-06-02

5. Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia;Bioorganic Chemistry;2024-06

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