Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma-Reference-Cited by-同舟云学术

Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma

Published:2017-08-31 Issue:9 Volume:130 Page:1114-1124
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Narita Tomoko¹,Ishida Takashi¹^ORCID,Ito Asahi¹,Masaki Ayako¹²,Kinoshita Shiori¹,Suzuki Susumu³,Takino Hisashi²,Yoshida Takashi¹,Ri Masaki¹,Kusumoto Shigeru¹,Komatsu Hirokazu¹,Imada Kazunori⁴,Tanaka Yuetsu⁵,Takaori-Kondo Akifumi⁶,Inagaki Hiroshi²,Scholz Arne⁷,Lienau Philip⁷,Kuroda Taruho⁸,Ueda Ryuzo³,Iida Shinsuke¹

Affiliation:

1. Department of Hematology and Oncology and

2. Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;

3. Department of Tumor Immunology, School of Medicine, Aichi Medical University, Aichi, Japan;

4. Department of Hematology, Osaka Red Cross Hospital, Osaka, Japan;

5. Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan;

6. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

7. Bayer AG Pharmaceuticals Division, Berlin, Germany; and

8. Bayer Yakuhin, Ltd, Osaka, Japan

Abstract

Key Points BAY 1143572, a novel and selective P-TEFb/CDK9 inhibitor, possessed significant antitumor activity against primary ATL cells in vitro. BAY 1143572 possessed significant antitumor activity in an ATL mouse model based on tumor cells from a patient.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/9/1114/1405260/blood741983.pdf

Reference45 articles.

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3. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma;Poiesz;Proc Natl Acad Sci USA,1980

4. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease;Yoshida;Proc Natl Acad Sci USA,1982

5. Antibody therapy for adult T-cell leukemia-lymphoma;Ishida;Int J Hematol,2011

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