Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors

Author:

Campiani Giuseppe1ORCID,Cavella Caterina1,Osko Jeremy D.2,Brindisi Margherita1ORCID,Relitti Nicola1ORCID,Brogi Simone3ORCID,Saraswati A. Prasanth1,Federico Stefano1ORCID,Chemi Giulia1ORCID,Maramai Samuele1ORCID,Carullo Gabriele1ORCID,Jaeger Benedikt4,Carleo Alfonso4,Benedetti Rosaria5ORCID,Sarno Federica5,Lamponi Stefania1,Rottoli Paola6,Bargagli Elena7,Bertucci Carlo8,Tedesco Daniele8ORCID,Herp Daniel9,Senger Johanna9,Ruberti Giovina10ORCID,Saccoccia Fulvio10,Saponara Simona11,Gorelli Beatrice11,Valoti Massimo11,Kennedy Breándan12ORCID,Sundaramurthi Husvinee12,Butini Stefania1ORCID,Jung Manfred9ORCID,Roach Katy M.13,Altucci Lucia5,Bradding Peter13,Christianson David W.2ORCID,Gemma Sandra1ORCID,Prasse Antje4

Affiliation:

1. Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy

2. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States

3. Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy

4. Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany

5. Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy

6. Specialization School of Respiratory Diseases, Department of Medical Sciences, Surgery and Neurosciences, Centro didattico Le Scotte, University of Siena, 53100 Siena, Italy

7. Department of Medical Sciences, Surgery and Neurosciences, Respiratory Diseases Unit, AOUS, Centro didattico Le Scotte, University of Siena, 53100 Siena, Italy

8. Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, Bologna 40126, Italy

9. Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany

10. Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo (Rome), Italy

11. Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy

12. UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland

13. Department of Respiratory Sciences, University of Leicester, UK, Institute of Lung Health and NIHR Leicester BRC-Respiratory, LE5 4PW Leicester, U.K.

Funder

NIH Clinical Center

Regione Toscana

Argonne National Laboratory

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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