Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation-Reference-Cited by-同舟云学术

Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation

Published:2021-10-21 Issue:21 Volume:64 Page:15702-15715
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Lufeng¹,Ren Ren²,Sun Xiaolian³,Zou Yunting²,Shi Yiru²,Di Bin²^ORCID,Niu Miao-Miao²^ORCID

Affiliation:

1. School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China

2. Key Laboratory of Drug Quality Control and Pharmacovigilance, Jiangsu Key Laboratory of Drug Design and Optimization, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China

3. State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China

Funder

Ministry of Science and Technology of the People's Republic of China

China Pharmaceutical University

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

MOE Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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