Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction-Reference-Cited by-同舟云学术

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Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

Published:2021-07-16 Issue:15 Volume:64 Page:11195-11218
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Zilu¹²,Zhang Min¹,Teuscher Kevin B.¹³,Ji Haitao¹²^ORCID

Affiliation:

1. Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States

2. Departments of Oncologic Sciences and Chemistry, University of South Florida, Tampa, Florida 33612-9497, United States

3. Department of Chemistry, Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah 84112-0850, United States

Funder

National Cancer Institute

Moffitt Cancer Center

Susan G. Komen

Floridian Breast Cancer Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00596

Reference77 articles.

1. Wnt/β-Catenin Signaling and Disease

2. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

3. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

4. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

5. Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

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1. Blocking the WNT/β-catenin pathway in cancer treatment:pharmacological targets and drug therapeutic potential;Heliyon;2024-08

2. Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells;Journal of Medicinal Chemistry;2024-06-24

3. Medicinal Chemistry Strategies for the Development of Inhibitors Disrupting β-Catenin’s Interactions with Its Nuclear Partners;Journal of Medicinal Chemistry;2022-12-30

4. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities;European Journal of Medicinal Chemistry;2022-12

5. Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives;European Journal of Medicinal Chemistry;2022-12

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