Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins-Reference-Cited by-同舟云学术

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

Published:2021-10-15 Issue:20 Volume:64 Page:15477-15502
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bond Adam G.¹^ORCID,Craigon Conner¹,Chan Kwok-Ho¹^ORCID,Testa Andrea¹,Karapetsas Athanasios²,Fasimoye Rotimi²^ORCID,Macartney Thomas²^ORCID,Blow J. Julian³^ORCID,Alessi Dario R.²^ORCID,Ciulli Alessio¹^ORCID

Affiliation:

1. Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

2. MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

3. Centre for Gene Regulation & Expression, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

Funder

Medical Research Council

Medical Research Scotland

H2020 Societal Challenges

Wellcome Trust

FP7 Ideas: European Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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