Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation-Reference-Cited by-同舟云学术

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

Published:2021 Issue:3 Volume:2 Page:725-742
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Bond Michael J.¹²³⁴,Crews Craig M.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacology

2. Yale University

3. New Haven

4. USA

5. Department of Molecular, Cellular, and Developmental Biology

Abstract

With the discovery of PROteolysis TArgeting Chimeras (PROTACs) twenty years ago, targeted protein degradation (TPD) has changed the landscape of drug development.

Funder

American Cancer Society

National Institute of General Medical Sciences

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00011J

Reference140 articles.

1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

2. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

3. PROteolysis TArgeting Chimeras (PROTACs) — Past, present and future

4. Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective

5. PROTACs: An Emerging Therapeutic Modality in Precision Medicine

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