Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A-Reference-Cited by-同舟云学术

Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A

Published:2021-10-26 Issue:21 Volume:64 Page:15883-15911
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wortmann Lars¹^ORCID,Bräuer Nico¹^ORCID,Holton Simon J.¹,Irlbacher Horst¹,Weiske Jörg¹,Lechner Christian¹,Meier Robin¹,Karén Jakob²,Siöberg Catrine Berthold²,Pütter Vera¹,Christ Clara D.¹^ORCID,ter Laak Antonius¹,Lienau Philip¹,Lesche Ralf¹,Nicke Barbara¹,Cheung Shing-Hu¹,Bauser Marcus¹,Haegebarth Andrea¹,von Nussbaum Franz¹,Mumberg Dominik¹,Lemos Clara¹

Affiliation:

1. Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany

2. Pelago Bioscience AB, Banvaktsvägen 20, 171 48 Solna, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01245

Reference47 articles.

1. PIP4K and the role of nuclear phosphoinositides in tumour suppression

2. Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors