Silver Catalyzed Cascade Strategy for the Synthesis of Diversely Substituted Polycyclic Fused 1,7‐Naphthyridine Scaffolds

Abstract

AbstractA one‐pot synthesis of diversely substituted polycyclic fused 1,7‐naphthyridines has been achieved via a silver‐catalyzed domino reaction. In this protocol, ortho‐alkynyl quinolines/pyridines were reacted smoothly with substituted anthranilic acid/ anthranilamide and provided fused 1,7‐naphthyridines scaffolds in excellent yields and good functional group tolerance under mild conditions. This protocol is further applicable for gram scale synthesis. In this methodology, we proposed the mechanism with the help of control experiments.