Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity-Reference-Cited by-同舟云学术

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Published:2021-12-23 Issue:1 Volume:65 Page:562-578
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Steadman David¹^ORCID,Atkinson Benjamin N.¹^ORCID,Zhao Yuguang²^ORCID,Willis Nicky J.¹^ORCID,Frew Sarah¹,Monaghan Amy¹,Patel Chandni¹,Armstrong Emma¹,Costelloe Kathryn¹,Magno Lorenza¹,Bictash Magda¹,Jones E. Yvonne²^ORCID,Fish Paul V.¹^ORCID,Svensson Fredrik¹^ORCID

Affiliation:

1. Alzheimer’s Research UK UCL Drug Discovery Institute, University College London, The Cruciform Building, Gower Street, LondonWC1E 6BT, U.K.

2. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, OxfordOX3 7BN, U.K.

Funder

Cancer Research UK

Alzheimer's Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01735

Reference53 articles.

1. Notum deacylates Wnt proteins to suppress signalling activity

2. Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation