Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain-Reference-Cited by-同舟云学术

Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain

Published:2021-07-16 Issue:15 Volume:64 Page:11090-11128
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hartz Richard A¹^ORCID,Ahuja Vijay T.¹,Nara Susheel J.²,Kumar C.M. Vijaya²,Brown Jeffrey M.³,Bristow Linda J.³,Rajamani Ramkumar⁴,Muckelbauer Jodi K.⁵,Camac Daniel⁵,Kiefer Susan E.⁶,Hunihan Lisa³,Gulianello Michael³,Lewis Martin³,Easton Amy³,Lippy Jonathan S.⁷,Surti Neha⁷,Pattipati Sreenivasulu N.²,Dokania Manoj²,Elavazhagan Saravanan²,Dandapani Kumaran²,Hamman Brian D.⁸,Allen Jason⁸,Kostich Walter³,Bronson Joanne J.¹,Macor John E.¹,Dzierba Carolyn D.¹

Affiliation:

1. Department of Small Molecule Drug Discovery, Bristol Myers Squibb Company, Research and Development, Wallingford, Connecticut 06492, United States

2. Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore 560099, India

3. Department of Neuroscience Discovery Biology, Bristol Myers Squibb Company, Research and Development, Wallingford, Connecticut 06492, United States

4. Department of Molecular Structure and Design, Bristol Myers Squibb Company, Research and Development, Wallingford, Connecticut 06492, United States

5. Department of Molecular Structure and Design, Bristol Myers Squibb Company, Research and Development, Princeton, New Jersey 08543, United States

6. Department of Protein Science, Bristol Myers Squibb Company, Research and Development, Princeton, New Jersey 08543, United States

7. Department of Lead Evaluation, Bristol Myers Squibb Company, Research and Development, Princeton, New Jersey 08543, United States

8. Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, Texas 77381, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00472

Reference74 articles.

1. Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

2. Neuropathic Pain: The Scope of the Problem

3. Epidemiology of Neuropathic Pain and Its Impact on Quality of Life

4. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

5. The evidence for pharmacological treatment of neuropathic pain

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