Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1-Reference-Cited by-同舟云学术

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

Published:2021-11-08 Issue:24 Volume:64 Page:17753-17776
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Come Jon H.¹,Senter Timothy J.¹^ORCID,Clark Michael P.¹^ORCID,Court John J.¹,Gale-Day Zachary¹,Gu Wenxin¹,Krueger Elaine¹,Liang Jianglin¹^ORCID,Morris Mark¹,Nanthakumar Suganthini¹,O’Dowd Hardwin¹,Maltais Francois¹,Iyer Ganesh¹,Andreassi John¹,Boucher Christina¹,Considine Tony¹,Moody Cameron S.¹,Taylor William¹,Mohanty Arun K.¹,Huang Yulin¹,Zuccola Harmon¹,Coll Joyce¹,Bonanno Kenneth C.¹,Gagnon Kevin J.¹,Gan Lu¹,Lu Fan¹,Gao Hong¹,Chakilam Ananthisrinivas¹,Engtrakul Juntyma¹,Song Bin¹,Crawford Dan¹,Doyle Elisabeth¹,Kramer Tal¹,Vought Bryan¹,Phillips Jonathan¹,Kemper Raymond¹,Sanders Martin¹,Swett Rebecca¹,Furey Brinley¹,Winquist Ray¹,Bunnage Mark E.¹,Jackson Katrina L.¹,Charifson Paul S.¹,Magavi Sanjay S.¹

Affiliation:

1. Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00944

Reference55 articles.

1. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters

2. Adrenoleukodystrophy: Phenotypic variability and implications for therapy

3. Progression of myelopathy in males with adrenoleukodystrophy: towards clinical trial readiness

4. X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management

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1. Computational insight into structural basis of human ELOVL1 inhibition;Computers in Biology and Medicine;2023-05

2. Therapeutic Role of ELOVL in Neurological Diseases;ACS Omega;2023-03-08

3. The Role of Oxidative Stress and Inflammation in X-Link Adrenoleukodystrophy;Frontiers in Nutrition;2022-04-08

4. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1;Journal of Medicinal Chemistry;2021-12-06