Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1-Reference-Cited by-同舟云学术

Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1

Published:2021-12-06 Issue:24 Volume:64 Page:17777-17794
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boyd Michael J.¹^ORCID,Collier Philip N.¹^ORCID,Clark Michael P.¹^ORCID,Deng Hongbo¹,Kesavan Sarathy¹,Ronkin Steven M.¹,Waal Nathan¹,Wang Jian¹,Cao Jingrong¹,Li Pan¹,Come Jon¹,Davies Ioana¹,Duffy John P.¹,Cochran John E.¹,Court John J.¹,Chandupatla Kishan¹,Jackson Katrina L.¹,Maltais Francois¹,O’Dowd Hardwin¹,Boucher Christina¹,Considine Tony¹,Taylor William P.¹,Gao Hong¹,Chakilam Ananthisrinivas¹,Engtrakul Juntyma¹,Crawford Dan¹,Doyle Elizabeth¹,Phillips Jonathan¹,Kemper Raymond¹,Swett Rebecca¹,Empfield James¹,Bunnage Mark E.¹,Charifson Paul S.¹,Magavi Sanjay Shivayogi¹

Affiliation:

1. Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00948

Reference39 articles.

1. Newborn Screening for X-Linked Adrenoleukodystrophy

2. Adrenoleukodystrophy: Phenotypic variability and implications for therapy

3. Progression of myelopathy in males with adrenoleukodystrophy: towards clinical trial readiness

4. X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management

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1. Computational insight into structural basis of human ELOVL1 inhibition;Computers in Biology and Medicine;2023-05

2. Therapeutic Role of ELOVL in Neurological Diseases;ACS Omega;2023-03-08

3. The Role of Oxidative Stress and Inflammation in X-Link Adrenoleukodystrophy;Frontiers in Nutrition;2022-04-08

4. Central Nervous System-Penetrant Inhibitors of ELOVL1;Synfacts;2022-02-16