Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design-Reference-Cited by-同舟云学术

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

Published:2021-10-15 Issue:21 Volume:64 Page:15868-15882
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yokoo Hidetomo¹,Shibata Norihito²^ORCID,Endo Akinori³,Ito Takahito¹,Yanase Yuta¹⁴,Murakami Yuki¹⁴,Fujii Kiyonaga⁵,Hamamura Kengo⁶,Saeki Yasushi³,Naito Mikihiko⁷,Aritake Kosuke⁶,Demizu Yosuke¹⁴^ORCID

Affiliation:

1. Division of Organic Chemistry, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan

2. Division of Biochemistry, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan

3. Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

4. Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehirocho, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0045, Japan

5. Laboratory of Analytical Chemistry, Daiichi University of Pharmacy, 22-1 Tamagawa-machi, Minami-ku, Fukuoka-shi, Fukuoka 815-8511, Japan

6. Laboratory of Chemical Pharmacology, Daiichi University of Pharmacy, 22-1 Tamagawa-machi, Minami-ku, Fukuoka-shi, Fukuoka 815-8511, Japan

7. Laboratory of Targeted Protein Degradation, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Funder

Naito Foundation

Takeda Science Foundation

Japan Foundation of Applied Enzymology

Sumitomo Foundation

Japan Agency for Medical Research and Development

Kobayashi Foundation for Cancer Research

NOVARTIS Foundation (Japan) for the Promotion of Science

Japan Society for the Promotion of Science

Foundation for Promotion of Cancer Research in Japan

Publisher

American Chemical Society (ACS)