Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions

Author:

Kamaraj Rajamanikkam1ORCID,Ghosh Subhrojyoti2ORCID,Das Souvadra3,Sen Shinjini3,Kumar Priyanka3,Majumdar Madhurima3,Dasgupta Renesa3,Mukherjee Sampurna3,Das Shrimanti3,Ghose Indrilla3,Pavek Petr1,Raja Karuppiah Muruga Poopathi4,Chuturgoon Anil A.5ORCID,Anand Krishnan6ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic

2. Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India

3. Department of Biotechnology, Heritage Institute of Technology, Kolkata 700107, India

4. Department of Chemistry, School of Physical Sciences, Central University of Kerala, Tejaswini Hills, Periye, Kasaragod District, Kerala 671320, India

5. Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, Howard College Campus, University of KwaZulu-Natal, Durban 4041, South Africa

6. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, Free State 9300, South Africa

Funder

European Commission

Grantová Agentura, Univerzita Karlova

National Research Foundation

Universiteit van die Vrystaat

Publisher

American Chemical Society (ACS)

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