Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo

Author:

Khazan Negar1,Kim Kyu Kwang1,Hansen Jeanne N.2,Singh Niloy A.1,Moore Taylor1,Snyder Cameron W. A.1,Pandita Ravina1,Strawderman Myla3,Fujihara Michiko4,Takamura Yuta4ORCID,Jian Ye5,Battaglia Nicholas5,Yano Naohiro6,Teramoto Yuki7,Arnold Leggy A.8ORCID,Hopson Russell9,Kishor Keshav10ORCID,Nayak Sneha10ORCID,Ojha Debasmita10,Sharon Ashoke10ORCID,Ashton John M.11,Wang Jian12,Milano Michael T.13,Miyamoto Hiroshi7ORCID,Linehan David C.5,Gerber Scott A.513,Kawar Nada14,Singh Ajay P.15,Tabdanov Erdem D.16ORCID,Dokholyan Nikolay V.12,Kakuta Hiroki4ORCID,Jurutka Peter W.1718,Schor Nina F.19ORCID,Rowswell-Turner Rachael B.1,Singh Rakesh K.1ORCID,Moore Richard G.1

Affiliation:

1. Wilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States

2. Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, United States

3. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14624, United States

4. Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8530, Japan

5. Division of Surgery and of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14624, United States

6. Department of Surgery, Division of Surgical Research, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, United States

7. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14624, United States

8. Department of Chemistry and Biochemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, United States

9. Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States

10. Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, India

11. Genomics Core Facility, Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14624, United States

12. Department of Pharmacology and Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Penn State University, Hershey, Pennsylvania 17036, United States

13. Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 16424, United States

14. Center for Breast Health and Gynecologic Oncology, Mercy Medical Center, 271 Carew Street, Springfield, Massachusetts 01104, United States

15. Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, New Jersey 08019, United States

16. CytoMechanobiology Laboratory, Department of Pharmacology, Penn State College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17036, United States

17. School of Mathematical and Natural Sciences, Arizona State University, Health Futures Center, Phoenix, Arizona 85054, United States

18. University of Arizona College of Medicine, Phoenix, Arizona 85004, United States

19. Departments of Pediatrics, Neurology, and Neuroscience, University of Rochester Medical Center, Rochester, New York 14642, United States

Funder

National Center for Advancing Translational Sciences

National Institute on Aging

National Institute of General Medical Sciences

National Science Foundation

William H. Eilinger Endowment Award

Passan Foundation

Technology Development Fund, Ministry Of Defence Government Of India

Crosby’s Fund for Neuroblastoma Pediatric Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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