Facile access to the 2,2-difluoro-2,3-dihydrofuran skeleton without extra additives: DMF-promoted difluorocarbene formation of ClCF<sub>2</sub>CO<sub>2</sub>Na-Reference-Cited by-同舟云学术

Facile access to the 2,2-difluoro-2,3-dihydrofuran skeleton without extra additives: DMF-promoted difluorocarbene formation of ClCF₂CO₂Na

Published:2022 Issue:41 Volume:20 Page:8037-8041
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Zunsheng¹,Xie Xin¹,Chen Weiming¹,Luo Nianhua¹,Li Xiaoning²,Yu Fuchao³,Huang Jiuzhong¹^ORCID

Affiliation:

1. School of Pharmacy, Gannan Medical University, Ganzhou 341000, P. R. China

2. Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, P. R. China

3. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China

Abstract

A practical and facile difluorocarbene-triggered cycloaddition reaction of enaminones was developed, which delivered 2,2-difluoro-2,3-dihydrofurans without any extra additives.

Funder

Gannan Medical University

National Natural Science Foundation of China

Foundation of Jiangxi Educational Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01542K

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1. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)