Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site-Reference-Cited by-同舟云学术

Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site

Published:2022-01-04 Issue:3 Volume:65 Page:2388-2408
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Zhiqing^ORCID,Li Yi,Chen Haiying,Lai Hsien-Tsung,Wang Pingyuan,Wu Shwu-Yuan,Wold Eric A.^ORCID,Leonard Paul G.¹,Joseph Sarah¹,Hu Haitao,Chiang Cheng-Ming^ORCID,Brasier Allan R.²^ORCID,Tian Bing,Zhou Jia^ORCID

Affiliation:

1. Core for Biomolecular Structure and Function, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States

2. Institute for Clinical and Translational Research (ICTR), University of Wisconsin-Madison School of Medicine and Public Health, 4248 Health Sciences Learning Center, Madison, Wisconsin 53705, United States

Funder

National Cancer Institute

Crohn's and Colitis Foundation of America

Sanofi

National Institute of Allergy and Infectious Diseases

Cancer Prevention and Research Institute of Texas

Crohn's and Colitis Foundation

University of Texas Medical Branch

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01851

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5. BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection

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