Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors
Author:
Affiliation:
1. Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0914, Japan
2. Graduate School of Innovative Life Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
Funder
Takeda Science Foundation
Japan Society for the Promotion of Science
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00823
Reference61 articles.
1. An Evaluation of the Role of Prealbumin in the Binding of Thyroxine1
2. Diagnosis and Therapeutic Approaches to Transthyretin Amyloidosis
3. Transthyretin Amyloid Neuropathy: The Schwann Cell Hypothesis
4. Characterization of the Transthyretin Acid Denaturation Pathways by Analytical Ultracentrifugation: Implications for Wild-Type, V30M, and L55P Amyloid Fibril Formation
5. The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into Amyloid
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