Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin-Reference-Cited by-同舟云学术

Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin

Published:2023-11-01 Issue:22 Volume:66 Page:15511-15523
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yokoyama Takeshi¹^ORCID,Kusaka Katsuhiro²,Mizuguchi Mineyuki¹,Nabeshima Yuko¹,Fujiwara Satoru³^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0914, Japan

2. Neutron Industrial Application Promotion Center, Comprehensive Research Organization for Science and Society (CROSS), 162-1 Shirakata, Tokai 319-1106, Ibaraki, Japan

3. Institute for Quantum Biology, National Institutes for Quantum Science and Technology, 2-4 Shirakata, Tokai 319-1106, Ibaraki, Japan

Funder

Takeda Science Foundation

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01698

Reference56 articles.

1. Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments

2. Transthyretin: a multifaceted protein

3. The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

4. The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis

5. Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments

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