Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment-Reference-Cited by-同舟云学术

Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment

Published:2021-07-26 Issue:15 Volume:64 Page:10908-10918
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nguyen Phung¹²,Doan Phuong¹²,Rimpilainen Tatu³,Konda Mani Saravanan⁴,Murugesan Akshaya¹⁵,Yli-Harja Olli⁶⁷,Candeias Nuno R.³⁸^ORCID,Kandhavelu Meenakshisundaram¹²^ORCID

Affiliation:

1. Molecular Signaling Lab, Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland

2. BioMeditech and Tays Cancer Center, Tampere University, Hospital, P.O. Box 553, 33101 Tampere, Finland

3. Faculty of Engineering and Natural Sciences, Tampere University, 33101 Tampere, Finland

4. Scigen Research and Innovation Pvt Ltd, Periyar Technology Business Incubator, Thanjavur, Tamil Nadu 613403, India

5. Department of Biotechnology, Lady Doak College, Thallakulam, 625002 Madurai, India

6. Computational Systems Biology Group, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101 Tampere, Finland

7. Institute for Systems Biology, 1441N 34th Street, Seattle, Washington 98103-8904, United States

8. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

Funder

Jane ja Aatos Erkon SÃ¤Ã¤tiÃ¶

Biotieteiden ja YmpÃ¤ristÃ¶n Tutkimuksen Toimikunta

Suomen Kulttuurirahasto

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00277

Reference39 articles.

1. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

2. Diagnosis and treatment in neuro-oncology: an oncological perspective

3. Glioblastoma and Other Malignant Gliomas

4. Agonist-independent regulation of constitutively active G-protein-coupled receptors

5. CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

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