Affiliation:
1. School of Materials and Chemistry, Anhui Agricultural University
2. Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China
Abstract
AbstractA highly effective oxidation cross-coupling method involving para-cresol derivatives and malononitrile derivatives has been developed utilizing undivided electrolytic conditions. This electrochemical approach offers a robust route for synthesizing diverse malononitrile derivatives featuring quaternary carbon centers and incorporating para-phenol groups. Notably, the direct electrooxidation of the C(sp3)–H bond in the para-cresol derivative plays a crucial role in this process under electrolytic conditions. Various para-cresol derivatives and malononitrile derivatives with different substituents are readily compatible with this electrochemical transformation, affording coupling compounds in up to 99% yield.
Funder
National Natural Science Foundation of China
Chinese Academy of Sciences
Fundamental Research Funds for the Central Universities
Natural Science Foundation of Anhui Province