JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate-Reference-Cited by-同舟云学术

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate

Published:2021-09-23 Issue:19 Volume:64 Page:14175-14191
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rombouts Frederik J. R.¹^ORCID,Kusakabe Ken-ichi²^ORCID,Alexander Richard³,Austin Nigel¹,Borghys Herman¹,De Cleyn Michel¹,Dhuyvetter Deborah¹,Gijsen Harrie J. M.¹^ORCID,Hrupka Brian¹,Jacobs Tom¹,Jerhaoui Soufyan¹,Lammens Lieve¹,Leclercq Laurent¹,Tsubone Koichi²,Ueno Tatsuhiko²,Morimoto Kenji²,Einaru Shunsuke²,Sumiyoshi Hirokazu²,Van den Bergh An¹,Vos Ann¹,Surkyn Michel¹,Teisman Ard¹,Moechars Diederik¹

Affiliation:

1. Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium

2. Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

3. Janssen Research & Development, Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00935

Reference53 articles.

1. Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

2. Shapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease

3. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

4. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

5. A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. DRUG-INDUCED LIVER INJURY: MECHANISMS, METHODS FOR PRE-CLINICAL ASSESSMENT, AND A MEDICINAL CHEMIST’S PERSPECTIVE;Medicinal Chemistry Reviews;2023-11-16

2. An Analysis of Successful Hit-to-Clinical Candidate Pairs;Journal of Medicinal Chemistry;2023-05-24

3. Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies;Journal of Medicinal Chemistry;2023-04-28

4. Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds;Medicinal Research Reviews;2023-03-21

5. In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1;CNS Neuroscience & Therapeutics;2023-03-09