Syntheses of Morpholine-Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization-Reference-Cited by-同舟云学术

Syntheses of Morpholine-Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization

Published:2021-05-05 Issue:10 Volume:64 Page:6838-6855
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hofmeister Armin¹^ORCID,Jahn-Hofmann Kerstin¹,Brunner Bodo¹,Helms Mike W.¹,Metz-Weidmann Christiane¹,Krack Arne¹,Kurz Michael¹,Li Ziyu¹,Weitzenberg Merle M.²³,Pflimlin Elsa⁴,Plettenburg Oliver²³^ORCID,Scheidler Sabine¹

Affiliation:

1. Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany

2. Institute of Organic Chemistry, Center of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Hannover 30167, Germany

3. Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Institute of Medicinal Chemistry (IMC), Neuherberg 85764, Germany

4. Hospices Civils de Lyon, Lyon 69002, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00144

Reference40 articles.

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3. Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo

4. The Ashwell–Morell Receptor

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