Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down
Author:
Affiliation:
1. Sanofi R&D, Industrial Park Hoechst, Frankfurt am Main 65926, Germany
Funder
Sanofi
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00873
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1. Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides
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3. Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs
4. Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity
5. siRNA function in RNAi: A chemical modification analysis
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1. Enhancing or Quenching of a Mitochondria-Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+, and Stimulated Response of GSH;Analytical Chemistry;2023-12-13
2. Novel Dioxane- and Morpholino Nucleotide Analogues with Improved Off-Target Profiles in siRNAs;Synfacts;2022-12-16
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