Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Author:

Kiefer Alexander F.1ORCID,Bousis Spyridon12,Hamed Mostafa M.1ORCID,Diamanti Eleonora13,Haupenthal Jörg1,Hirsch Anna K.H.123ORCID

Affiliation:

1. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)−Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany

2. Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbrücken, Germany

3. Helmholtz International Lab for Anti-Infectives, Campus E8.1, 66123 Saarbrücken, Germany

Funder

FP7 People: Marie-Curie Actions

Helmholtz Association

H2020 European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference27 articles.

1. Ahmed, Y. A.; Anand, B.; Hanan Hassan, A. B.; Banerjee, S.; Bertagnolio, S.; Bruinsma, N.; Cavallier, P.; Chowdary, T.; Dean, A.; El Olmeri, N.; Eraly, E.; Escalante, S.; Escher, M.; Fuller, W.; Gahimbare, L.; Gelormini, M.; Giron, A. C.; Glaziou, P.; Gordon, B. A.; Ivanovska, V.; Iwamoto, K.; Jung, T. R.; Wong, D. L. F.; Matheu, J. R.; Alvarez, K. O. M.; Muller, A.; Nishijima, T.; O’Doherty, D.; Ramon-Pardo, P.; Rasmussen, C.; Ringwald, P.; Siswanto, S.; Lorenzo Subissi, M.; Ismail, T.; Tosas, O.; Van Weezenbeek, C.; Vong, S.; Wi, T. E.; Zamora, D. M.; Zayed, B. Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2021; 2021.

2. Critical analysis of antibacterial agents in clinical development

3. ECF-Type ATP-Binding Cassette Transporters

4. Transport of folate compounds into Lactobacillus casei

5. Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters

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