Hit optimization by dynamic combinatorial chemistry on <i>Streptococcus pneumoniae</i> energy-coupling factor transporter ECF-PanT-Reference-Cited by-同舟云学术

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Published:2024 Issue:7 Volume:60 Page:870-873
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Exapicheidou Ioulia Antonia¹²^ORCID,Shams Atanaz¹²^ORCID,Ibrahim Hamza³,Tsarenko Aleksei⁴,Backenköhler Michael³,Hamed Mostafa M.¹^ORCID,Diamanti Eleonora¹,Volkamer Andrea¹³^ORCID,Slotboom Dirk J.⁴,Hirsch Anna K. H.¹²^ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) – Helmholtz Centre for Infection Research (HZI), 66123, Saarbrücken, Germany

2. Saarland University, Department of Pharmacy, Campus Building E8.1, 66123, Saarbrücken, Germany

3. Data Driven Drug Design Group, Center for Bioinformatics, Saarland Informatics Campus E2.1, Saarland University, Saarbrücken 66123, Germany

4. Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, The Netherlands

Abstract

First application of dynamic combinatorial chemistry to the whole complex of the energy-coupling factor transporter PanT from Streptococcus pneumoniae.

Funder

European Research Council

Universität des Saarlandes

Helmholtz Association

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC04738E

Reference18 articles.

1. Energy-Coupling Factor Transporters as Novel Antimicrobial Targets

2. ECF-Type ATP-Binding Cassette Transporters

3. Structure of a bacterial energy-coupling factor transporter

4. Membrane mediated toppling mechanism of the folate energy coupling factor transporter

5. Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM

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