Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors

Published:2022-02-04 Issue:4 Volume:65 Page:3249-3265
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Zhen¹,Li Jie¹,Chen Hao¹,Huang Jing¹,Song Xiaojuan,Tu Zheng-Chao¹²,Zhang Zhang¹,Peng Lijie¹,Zhou Yang¹^ORCID,Ding Ke¹³⁴^ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, # 855 Xingye Avenue, Guangzhou 510632, China

2. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, # 160 Kaiyuan Avenue, Guangzhou 510530, China

3. The First Affiliated Hospital, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

4. State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, # 345 Lingling Road, Shanghai 200032, China

Funder

Guangdong Science and Technology Department

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

State Key Laboratory of Bioorganic and Nature Products Chemistry

Guangzhou City

Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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