The metal- and column-free synthesis of pyridin-2-yl ureas carrying cyclic secondary amine substituents and establishing the mechanism of the reactions through a computational study-Reference-Cited by-同舟云学术

The metal- and column-free synthesis of pyridin-2-yl ureas carrying cyclic secondary amine substituents and establishing the mechanism of the reactions through a computational study

Published:2023 Issue:13 Volume:10 Page:3182-3192
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liu Kai¹,Xie Yayu¹,Qin Yuan¹,Parmar Virinder S.²,Liu Yonghong¹,Cao Pei¹^ORCID

Affiliation:

1. Guangxi Key Laboratory of Marine Drugs/Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, PR China

2. Nanoscience Program, CUNY Graduate Center and Department of Chemistry, City College & Medgar Evers College, The City University of New York, 160 Convent Avenue, New York, NY 10031, USA

Abstract

Pyridyl ureas as potential ASK1 inhibitors were synthesized through auto-tandem rearrangement and subsequent one-pot aminolysis involving a more accessible concerted pathway.

Funder

Bagui Scholars Program of Guangxi Zhuang Autonomous Region

Education Department of Guangxi Zhuang Autonomous Region

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Guangxi University of Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00571B

Reference88 articles.