Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer-Reference-Cited by-同舟云学术

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

Published:2021-05-19 Issue:11 Volume:64 Page:7617-7629
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hu De-Xuan¹,Tang Wen-Lin¹,Zhang Yu¹,Yang Hao¹,Wang Wenjie²,Agama Keli²,Pommier Yves²^ORCID,An Lin-Kun¹³^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

2. Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892, Maryland, United States

3. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510006, China

Funder

National Cancer Institute

Guangdong Provincial Key Laboratory of Construction Foundation

Guangdong Basic and Applied Basic Research Foundation

Guangzhou Basic and Applied Basic Research Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00318