Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification-Reference-Cited by-同舟云学术

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

Published:2023 Issue:5 Volume:4 Page:334-343
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Zhao Xue Zhi¹^ORCID,Wang Wenjie²,Lountos George T.³^ORCID,Kiselev Evgeny²,Tropea Joseph E.⁴,Needle Danielle⁴,Pommier Yves²,Burke Terrence R.¹^ORCID

Affiliation:

1. Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA

2. Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

3. Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA

4. Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA

Abstract

A click-based oxime protocol to extend small molecule microarray-derived TDP1 inhibitory platform to project into the DNA and TOP1 peptide substrate-binding channels.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D2CB00230B

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