New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition

Author:

Zahid Huda1ORCID,Buchholz Caroline R.2,Singh Manjulata3,Ciccone Michael F.4,Chan Alice5,Nithianantham Stanley6,Shi Ke7ORCID,Aihara Hideki7ORCID,Fischer Marcus6,Schönbrunn Ernst5ORCID,dos Santos Camila O.4,Landry Joseph W.3,Pomerantz William C. K.12ORCID

Affiliation:

1. Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States

2. Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States

3. The Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, United States

4. Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, United States

5. Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, United States

6. Department of Chemical Biology & Therapeutics and Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

7. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, Minnesota 55455, United States

Funder

National Cancer Institute

U.S. Department of Defense

National Institute on Aging

American Lebanese Syrian Associated Charities

University of Minnesota

National Institutes of Health

National Institute of General Medical Sciences

Cold Spring Harbor Laboratory

Northwell Health Affiliation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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