Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1-Reference-Cited by-同舟云学术

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Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1

Published:2021-04-20 Issue:9 Volume:64 Page:5838-5849
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Spinck Martin¹,Bischoff Matthias²,Lampe Philipp²,Meyer-Almes Franz-Josef³^ORCID,Sievers Sonja²,Neumann Heinz¹³^ORCID

Affiliation:

1. Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany

2. Compound Management and Screening Center, Dortmund, Otto-Hahn-Str. 11, Dortmund 44227, Germany

3. Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstrasse 7, Darmstadt 64295, Germany

Funder

Behrens-Weise-Foundation

Max-Planck Institute of Molecular Physiology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00017

Reference38 articles.

1. NAD+ and sirtuins in aging and disease

2. SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

3. Caloric restriction, SIRT1 and longevity

4. Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin

5. SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

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