Discovery of Novel Apigenin–Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of Novel Apigenin–Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Published:2021-08-18 Issue:16 Volume:64 Page:12089-12108
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Long Huan¹,Hu Xiaolong¹,Wang Baolin¹,Wang Quan¹,Wang Rong¹,Liu Shumeng¹,Xiong Fei²^ORCID,Jiang Zhenzhou³,Zhang Xiao-Qi⁴^ORCID,Ye Wen-Cai⁴^ORCID,Wang Hao¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China

2. State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, People’s Republic of China

3. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, People’s Republic of China

4. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, People’s Republic of China

Funder

Ministry of Science and Technology of the People's Republic of China

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Jiangsu Province Graduate Student Training Innovation Project

Funding of Double First-rate Discipline Innovation Team

Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program

Research and Innovation Project for College Graduates of Jiangsu Province 2017

Publisher

American Chemical Society (ACS)