Synthesis and In Silico Evaluation of Piperazine-Substituted 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone Derivatives as Potential PARP-1 Inhibitors-Reference-Cited by-同舟云学术

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Synthesis and In Silico Evaluation of Piperazine-Substituted 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone Derivatives as Potential PARP-1 Inhibitors

Published:2024-09-10 Issue: Volume: Page:
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Nemetova Ulviyye¹,Si̇yah Pınar²^ORCID,Boran Tuğçe³,Bi̇lgi̇ Çiğdem⁴,Özyürek Mustafa⁵,Şahi̇nler Ayla Sibel¹

Affiliation:

1. Engineering Faculty, Department of Chemistry, Organic Chemistry, Istanbul University-Cerrahpaşa, 34320 Istanbul, Turkey

2. Department of Biochemistry, Faculty of Pharmacy, Bahcesehir University, 34353 Istanbul, Turkey

3. Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul University-Cerrahpaşa, 34500 Istanbul, Turkey

4. Faculty of Pharmacy, Department of Pharmacognosy, Istanbul University-Cerrahpaşa, 34500 Istanbul, Turkey

5. Engineering Faculty, Department of Chemistry, Analytical Chemistry, Istanbul University-Cerrahpaşa, 34320 Istanbul, Turkey

Funder

Istanbul ?niversitesi-Cerrahpasa

Bah?esehir ?niversitesi

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c04915

Reference45 articles.

1. Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus

2. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

3. Genetic Interactions in Cancer Progression and Treatment

4. PARP inhibitors: Synthetic lethality in the clinic

5. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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