Structure–Activity Relationship of USP5 Inhibitors-Reference-Cited by-同舟云学术

Structure–Activity Relationship of USP5 Inhibitors

Published:2021-10-14 Issue:20 Volume:64 Page:15017-15036
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mann Mandeep K.¹²^ORCID,Zepeda-Velázquez Carlos A.³^ORCID,González-Álvarez Héctor²³,Dong Aiping¹,Kiyota Taira³,Aman Ahmed M.³⁴^ORCID,Loppnau Peter¹,Li Yanjun¹,Wilson Brian³,Arrowsmith Cheryl H.¹⁵⁶^ORCID,Al-Awar Rima²³^ORCID,Harding Rachel J.¹^ORCID,Schapira Matthieu¹²^ORCID

Affiliation:

1. Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS South Tower, Suite 700, Toronto, Ontario M5G 1L7, Canada

2. Department of Pharmacology and Toxicology, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada

3. Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada

4. Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada

5. Princess Margaret Cancer Centre, 661 University Avenue, Toronto, Ontario M5G 2C4, Canada

6. Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

Funder

Huntington's Disease Society of America

Consejo Nacional de Ciencia y Tecnolog??a

Natural Sciences and Engineering Research Council of Canada

Structural Genomics Consortium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00889

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4. The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

5. Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2

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