Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ3-Reference-Cited by-同舟云学术

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Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ3

Published:2021-11-03 Issue:21 Volume:64 Page:16008-16019
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mizuno Yuki¹²³^ORCID,Kimura Kohta¹,Onoe Satoru¹,Shukuri Miho¹,Kuge Yuji²³,Akizawa Hiromichi¹^ORCID

Affiliation:

1. Laboratory of Physical Chemistry, Showa Pharmaceutical University, Machida 194-8543, Japan

2. Central Institute of Isotope Science, Hokkaido University, Sapporo 060-0815, Japan

3. Department of Biomedical Imaging, Graduate School of Biomedical Science and Engineering, Hokkaido University, Sapporo 060-8638, Japan

Funder

Japan Science Society

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01396

Reference29 articles.

1. Synthetic multivalent ligands in the exploration of cell-surface interactions

2. Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

3. Synthetic Multivalent Ligands as Probes of Signal Transduction

4. Multivalency as a Chemical Organization and Action Principle

5. Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

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3. The importance of tyrosines in multimers of cyclic RGD nonapeptides: towards αvβ6-integrin targeted radiotherapeutics;RSC Medicinal Chemistry;2024

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5. Synthesis and Evaluation of ^99mTc-Labeled FAP Inhibitors with Different Linkers for Imaging of Fibroblast Activation Proteins in Tumors;Journal of Medicinal Chemistry;2023-03-27

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