The importance of tyrosines in multimers of cyclic RGD nonapeptides: towards αvβ6-integrin targeted radiotherapeutics-Reference-Cited by-同舟云学术

The importance of tyrosines in multimers of cyclic RGD nonapeptides: towards αvβ6-integrin targeted radiotherapeutics

Published:2024 Issue:6 Volume:15 Page:2018-2029
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Quigley Neil Gerard¹,Zierke Maximilian Alexander¹,Ludwig Beatrice Stefanie²,Richter Frauke¹,Nguyen Nghia Trong²,Reissig Falco³,Šimeček Jakub³,Kossatz Susanne²,Notni Johannes¹³^ORCID

Affiliation:

1. Institute of Pathology, School of Medicine and Health, Technische Universität München, Munich, Germany

2. Department of Nuclear Medicine, University Hospital Klinikum Rechts der Isar and Central Institute for Translational Cancer Research, (TranslaTUM), School of Medicine and Health, Technische Universität München, Munich, Germany

3. TRIMT GmbH, Carl-Eschebach-Str. 7, D-01454 Radeberg, Germany

Abstract

Tyrosines preferred: tetramers of αvβ6-integrin binding cyclopeptides show more favorable biodistribution (less nonspecific uptake) the more tyrosines they contain, which can not be deduced from the in vitro properties of the peptide monomers.

Funder

Sächsische Aufbaubank

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00073K

Reference65 articles.

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4. Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle–Receptor Interactions

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