Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening-Reference-Cited by-同舟云学术

Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

Published:2022-02-10 Issue:4 Volume:65 Page:3266-3305
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lee Sang-Woo¹,Tran Kim Tai¹²,Vazquez-Uribe Ruben¹,Gotfredsen Charlotte Held³,Clausen Mads Hartvig⁴^ORCID,Mendez Blanca Lopez⁵,Montoya Guillermo⁵,Bach Anders²^ORCID,Sommer Morten Otto Alexander¹^ORCID

Affiliation:

1. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark

2. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark

3. Department of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark

4. Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark

5. Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark

Funder

Danmarks Tekniske Universitet

Novo Nordisk Fonden

Uddannelses- og Forskningsministeriet

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01834

Reference44 articles.

1. The new frontier of genome engineering with CRISPR-Cas9

2. Development and Applications of CRISPR-Cas9 for Genome Engineering

3. The chemistry of Cas9 and its CRISPR colleagues

4. CRISPR/Cas9 in Genome Editing and Beyond

5. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

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